Koyukuk-Middle Yukon Census Subarea is a civil located in Yukon-Koyukuk County, Alaska. It appears on the Melozitna C-1 NW USGS 7.5-minute topographic quadrangle. The elevation at this location is approximately 1,525.82 feet (465.07 m) above sea level. The nearest populated place is Hughes, approximately 35.1 miles to the NW.