Lofty Gulch is a valley located in Yukon-Koyukuk County, Alaska. It appears on the Wiseman B-1 NE USGS 7.5-minute topographic quadrangle. The elevation at this location is approximately 1,319.62 feet (402.22 m) above sea level. The nearest populated place is Nolan, approximately 3.8 miles to the W.